HAO1

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]

Description

Hydroxyacid oxidase 1

Tissue specificity

Tissue enriched (liver)

Predicted location

Intracellular

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (7882985 - 7940458)

Ensembl ID

ENSG00000101323  (ver. 103.38)

Orthologs

Mouse Hao1: ENSMUSG00000027261

UniProt

Q9UJM8

neXtProt

NX_Q9UJM8

Human splice variants
Mouse splice variants

Protein structure