LYRM1

The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Description

LYR motif containing 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Midbody

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (20899868 - 20925006)

Ensembl ID

ENSG00000102897  (ver. 103.38)

Orthologs

Mouse Lyrm1: ENSMUSG00000030922

UniProt

O43325

neXtProt

NX_O43325

Human splice variants
Mouse splice variants

Protein structure