Tissue expression
Cell line expression
Protein structure
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidaseAPAA, UCE
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015]
Top validated antibodies |
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LSBio | LS-C680919 | Polyclonal |
WB
EL
IHC
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Cusabio Biotech Co., Ltd | CSB-PA015417LA01HU | Polyclonal |
WB
EL
IHC
|
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Biorbyt | orb221594 | Polyclonal |
EL
ICC
IHC
|
||
antibodies-online | ABIN2444545 | Polyclonal |
WB
|
||
Aviva Systems Biology | ARP47241_P050 | Polyclonal |
WB
|
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