Tissue expression
Cell line expression
Protein structure
CASP2
Caspase 2ICH1, MGC2181, NEDD2, PPP1R57
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Top validated antibodies |
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| Proteintech Group | 8 references | Polyclonal |
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| antibodies-online | 3 references | Polyclonal |
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| LSBio | Polyclonal |
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| Invitrogen Antibodies | Polyclonal |
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| Enzo Life Sciences | 12 references | Monoclonal |
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