NMRK1

Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]). [supplied by OMIM, Mar 2008]

Description

Nicotinamide riboside kinase 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (75060573 - 75088217)

Ensembl ID

ENSG00000106733  (ver. 103.38)

Orthologs

Mouse Nmrk1: ENSMUSG00000037847

UniProt

Q9NWW6

neXtProt

NX_Q9NWW6

Human splice variants
Mouse splice variants

Protein structure