FOXN1

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

Description

Forkhead box N1

Tissue specificity

Group enriched (esophagus, lymphoid tissue, skin , vagina)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

17 (28506243 - 28538900)

Ensembl ID

ENSG00000109101  (ver. 103.38)

Orthologs

Mouse Foxn1: ENSMUSG00000002057

UniProt

O15353

neXtProt

NX_O15353

Human splice variants
Mouse splice variants

Protein structure