LAMTOR3

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

Description

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (99878336 - 99894428)

Ensembl ID

ENSG00000109270  (ver. 103.38)

Orthologs

Mouse Lamtor3: ENSMUSG00000091512

UniProt

Q9UHA4

neXtProt

NX_Q9UHA4

Human splice variants
Mouse splice variants

Protein structure