DDX25

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]

Description

DEAD-box helicase 25

Tissue specificity

Tissue enriched (testis)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

11 (125903348 - 125943702)

Ensembl ID

ENSG00000109832  (ver. 103.38)

Orthologs

Mouse Ddx25: ENSMUSG00000032101

UniProt

Q9UHL0

neXtProt

NX_Q9UHL0

Human splice variants
Mouse splice variants

Protein structure