P2RX3

This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]

Description

Purinergic receptor P2X 3

Tissue specificity

Tissue enhanced (heart muscle, liver, testis)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

11 (57338352 - 57372396)

Ensembl ID

ENSG00000109991  (ver. 103.38)

Orthologs

Mouse P2rx3: ENSMUSG00000027071

UniProt

P56373

neXtProt

NX_P56373

Human splice variants
Mouse splice variants

Protein structure