Tissue expression
Cell line expression
Protein structure
SNX15
Sorting nexin 15This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
Top validated antibodies |
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Atlas Antibodies | HPA038955 | Polyclonal |
WB
ICC
IHC
|
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Invitrogen Antibodies | PA5-83444 | Polyclonal |
WB
ICC
IHC
|
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antibodies-online | ABIN4354984 | Polyclonal |
WB
ICC
IHC
|
||
Novus Biologicals | NB100-1210 | 1 references | Polyclonal |
WB
EL |
|
Cusabio Biotech Co., Ltd | CSB-PA882091LA01HU | Polyclonal |
EL
ICC
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider