EHD1

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Description

EH domain containing 1

Tissue specificity

Tissue enhanced (bone marrow, testis)

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (64851642 - 64888296)

Ensembl ID

ENSG00000110047  (ver. 103.38)

Orthologs

Mouse Ehd1: ENSMUSG00000024772

UniProt

Q9H4M9

neXtProt

NX_Q9H4M9

Human splice variants
Mouse splice variants

Protein structure