ENDOU

This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

Description

Endonuclease, poly(U) specific

Tissue specificity

Group enriched (esophagus, salivary gland, skin , vagina)

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (47709734 - 47725567)

Ensembl ID

ENSG00000111405  (ver. 103.38)

Orthologs

Mouse Endou: ENSMUSG00000022468

UniProt

P21128

neXtProt

NX_P21128

Human splice variants
Mouse splice variants

Protein structure