OPRM1

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

Description

Opioid receptor mu 1

Tissue specificity

Group enriched (brain, testis)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

6 (154010496 - 154246867)

Ensembl ID

ENSG00000112038  (ver. 103.38)

Orthologs

Mouse Oprm1: ENSMUSG00000000766

UniProt

P35372

neXtProt

NX_P35372

Human splice variants
Mouse splice variants

Protein structure