FHL5

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]

Description

Four and a half LIM domains 5

Tissue specificity

Tissue enhanced (testis)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

6 (96562548 - 96616636)

Ensembl ID

ENSG00000112214  (ver. 103.38)

Orthologs

Mouse Fhl5: ENSMUSG00000028259

UniProt

Q5TD97

neXtProt

NX_Q5TD97

Human splice variants
Mouse splice variants

Protein structure