APBB3

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Amyloid beta precursor protein binding family B member 3

Tissue specificity

Tissue enhanced (brain)

Subcell location

Actin filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

5 (140558268 - 140564781)

Ensembl ID

ENSG00000113108  (ver. 103.38)

Orthologs

Mouse Apbb3: ENSMUSG00000117679

UniProt

O95704

neXtProt

NX_O95704

Human splice variants
Mouse splice variants

Protein structure