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Protein structure
IL4
Interleukin 4BCGF-1, BCGF1, BSF1, IL-4, MGC79402
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| GeneTex |  GTX15806 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
BN
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| Invitrogen Antibodies | PA5-25165 |
8 references | Polyclonal |
WB
IHC
FC
OA
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| Proteintech Group | 66142-1-Ig |
15 references | Monoclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NB100-64798 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| R&D Systems | AF654 |
3 references | Polyclonal |
WB
EL
ICC
BN
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