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ACVR1
Activin A receptor type 1ACVR1A, ACVRLK2, ALK2, SKR1
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  NBP2-61799 |
Monoclonal |
WB
EL
ICC
IHC
FC
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| R&D Systems | AF637 |
4 references | Polyclonal |
WB
IHC
FC
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| LSBio | LS-C682506 |
Monoclonal |
WB
EL
ICC
IHC
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| Proteintech Group | 67417-1-Ig |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN5681704 |
Monoclonal |
WB
EL
ICC
IHC
FC
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