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Cell line expression
Protein structure
GGCX
Gamma-glutamyl carboxylaseVKCFD1
This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Top validated antibodies |
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| Proteintech Group |  16209-1-AP |
6 references | Polyclonal |
WB
EL
IP
IHC
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| LSBio | LS-C401710 |
Polyclonal |
WB
EL
IHC
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| GeneTex | GTX109926 |
1 references | Polyclonal |
WB
ICC
IHC
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| Invitrogen Antibodies | 16209-1-AP |
Polyclonal |
WB
IP
IHC
OA
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| Novus Biologicals | NBP1-51964 |
1 references | Polyclonal |
WB
EL
IHC
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