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Protein structure
IL1R2
Interleukin 1 receptor type 2CD121b, IL1RB
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Top validated antibodies |
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| Novus Biologicals |  NBP1-32681 |
2 references | Polyclonal |
WB
ICC
IHC
ChIP
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| Proteintech Group | 60262-1-Ig |
4 references | Monoclonal |
WB
EL
ICC
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| R&D Systems | AF-263-NA |
3 references | Polyclonal |
WB
ICC
BN
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| OriGene | AP07592PU-N |
Polyclonal |
WB
EL
ICC
IP
IHC
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| GeneTex | GTX108702 |
1 references | Polyclonal |
WB
ICC
IHC
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