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Protein structure
ABCG2
ATP binding cassette subfamily G member 2 (Junior blood group)ABCP, BCRP, CD338, EST157481, MXR
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Top validated antibodies |
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| Novus Biologicals |  NBP2-22124 |
4 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX60447 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| OriGene | TA336921 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Acris Antibodies GmbH | AM06628SU-N |
Monoclonal |
WB
EL
ICC
IHC
FC
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| Abnova Corporation | MAB10478 |
Monoclonal |
WB
EL
ICC
IHC
FC
|
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