ADRA1A

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Description

Adrenoceptor alpha 1A

Tissue specificity

Tissue enhanced (adipose tissue, brain, liver)

Subcell location

Nucleoplasm, Vesicles, Cytosol

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

8 (26748150 - 26867278)

Ensembl ID

ENSG00000120907  (ver. 103.38)

Orthologs

Mouse Adra1a: ENSMUSG00000045875

UniProt

P35348

neXtProt

NX_P35348

Human splice variants
Mouse splice variants

Protein structure