Tissue expression
Cell line expression
Protein structure
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1IB1, JIP-1, JIP1, PRKM8IP
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Top validated antibodies |
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Proteintech Group | 14568-1-AP | 6 references | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | 34-5200 | 2 references | Polyclonal |
WB
ICC
IP
OA |
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antibodies-online | ABIN2842613 | 1 references | Polyclonal |
WB
ICC
IHC
FC |
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NSJ Bioreagents | F55015 | Polyclonal |
WB
ICC
IHC
FC |
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Boster Biological Technology | A05068T103 | Polyclonal |
WB
EL
ICC
IHC |
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