ADGRE5

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Description

Adhesion G protein-coupled receptor E5

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Cytosol

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

CD markers
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

19 (14380501 - 14408725)

Ensembl ID

ENSG00000123146  (ver. 103.38)

Orthologs

Mouse Adgre5: ENSMUSG00000002885

UniProt

P48960

neXtProt

NX_P48960

Human splice variants
Mouse splice variants

Protein structure