PFDN5

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

Prefoldin subunit 5

Tissue specificity

Low tissue specificity

Subcell location

Intermediate filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (53295291 - 53299452)

Ensembl ID

ENSG00000123349  (ver. 103.38)

Orthologs

Mouse Pfdn5: ENSMUSG00000001289

UniProt

Q99471

neXtProt

NX_Q99471

Human splice variants
Mouse splice variants

Protein structure