NRN1

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Description

Neuritin 1

Tissue specificity

Tissue enhanced (brain, parathyroid gland)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

6 (5997999 - 6007605)

Ensembl ID

ENSG00000124785  (ver. 103.38)

Orthologs

Mouse Nrn1: ENSMUSG00000039114

UniProt

Q9NPD7

neXtProt

NX_Q9NPD7

Human splice variants
Mouse splice variants

Protein structure