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Protein structure
IRF1
Interferon regulatory factor 1MAR
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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| Proteintech Group |  11335-1-AP |
16 references | Polyclonal |
WB
EL
IP
IHC
FC
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| Invitrogen Antibodies | A700-039 |
Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| NSJ Bioreagents | RQ6056 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Novus Biologicals | NBP2-67330 |
Monoclonal |
WB
ICC
IP
IHC
FC
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| antibodies-online | ABIN393910 |
5 references | Monoclonal |
WB
EL
IHC
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