PRRG2

The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Description

Proline rich and Gla domain 2

Tissue specificity

Tissue enhanced (parathyroid gland)

Subcell location

Nucleoplasm, Nucleoli, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

19 (49580646 - 49591004)

Ensembl ID

ENSG00000126460  (ver. 103.38)

Orthologs

Mouse Prrg2: ENSMUSG00000007837

UniProt

O14669

neXtProt

NX_O14669

Human splice variants
Mouse splice variants

Protein structure