Tissue expression
Cell line expression
Protein structure
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4BAF190, BRG1, FLJ39786, hSNF2b, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Top validated antibodies |
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Proteintech Group | 21634-1-AP | 18 references | Polyclonal |
WB
EL
ICC
IP
IHC
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Novus Biologicals | NB100-2594 | 4 references | Polyclonal |
WB
IP
IHC
ChIP |
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Invitrogen Antibodies | MA5-31550 | 1 references | Monoclonal |
WB
ICC
IHC
OA |
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antibodies-online | ABIN4285248 | Polyclonal |
WB
ICC
IP
IHC |
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OriGene | TA347050 | 1 references | Monoclonal |
WB
ICC
IP
|
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Supportive data in Antibodypedia
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Recommended by provider