GAL3ST1

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

Galactose-3-O-sulfotransferase 1

Tissue specificity

Tissue enhanced (brain, intestine)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

22 (30554635 - 30574665)

Ensembl ID

ENSG00000128242  (ver. 103.38)

Orthologs

Mouse Gal3st1: ENSMUSG00000049721

UniProt

Q99999

neXtProt

NX_Q99999

Human splice variants
Mouse splice variants

Protein structure