Tissue expression
Cell line expression
Protein structure
APOBEC3A
Apolipoprotein B mRNA editing enzyme catalytic subunit 3AARP3, PHRBN
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Top validated antibodies |
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OriGene | AP31973PU-N | Polyclonal |
WB
EL
ICC
IHC
FC
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Everest Biotech | EB08268 | Polyclonal |
WB
EL
ICC
IHC
FC
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Invitrogen Antibodies | PA5-142329 | Polyclonal |
WB
ICC
IHC
FC |
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Biorbyt | orb1246686 | Polyclonal |
WB
EL
ICC
IHC
FC
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antibodies-online | ABIN2846501 | 2 references | Polyclonal |
WB
IHC |
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