Tissue expression
Cell line expression
Protein structure
DUT
Deoxyuridine triphosphatasedUTPase
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Proteintech Group | 13740-1-AP | 3 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Abnova Corporation | H00001854-M01 | 1 references | Monoclonal |
WB
EL
ICC
IHC |
|
antibodies-online | ABIN560672 | 1 references | Monoclonal |
WB
EL
ICC
IHC |
|
OriGene | AM20882PU-N | Monoclonal |
WB
EL
ICC
IHC |
||
Acris Antibodies GmbH | AM20882PU-N | Monoclonal |
WB
EL
ICC
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider