LRCH2

This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Description

Leucine rich repeats and calponin homology domain containing 2

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (115110616 - 115234096)

Ensembl ID

ENSG00000130224  (ver. 103.38)

Orthologs

Mouse Lrch2: ENSMUSG00000031290

UniProt

Q5VUJ6

neXtProt

NX_Q5VUJ6

Human splice variants
Mouse splice variants

Protein structure