PRRG1

This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Description

Proline rich and Gla domain 1

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (37349309 - 37457292)

Ensembl ID

ENSG00000130962  (ver. 103.38)

Orthologs

Mouse Prrg1: ENSMUSG00000047996

UniProt

O14668

neXtProt

NX_O14668

Human splice variants
Mouse splice variants

Protein structure