PRKAA1

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Description

Protein kinase AMP-activated catalytic subunit alpha 1

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (40759379 - 40798374)

Ensembl ID

ENSG00000132356  (ver. 103.38)

Orthologs

Mouse Prkaa1: ENSMUSG00000050697

UniProt

Q13131

neXtProt

NX_Q13131

Human splice variants
Mouse splice variants

Protein structure