ATP1A4

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

ATPase Na+/K+ transporting subunit alpha 4

Tissue specificity

Tissue enhanced (placenta, testis, urinary bladder)

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (160151586 - 160186980)

Ensembl ID

ENSG00000132681  (ver. 103.38)

Orthologs

Mouse Atp1a4: ENSMUSG00000007107

UniProt

Q13733

neXtProt

NX_Q13733

Human splice variants
Mouse splice variants

Protein structure