RNF128

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Description

Ring finger protein 128

Tissue specificity

Tissue enhanced (intestine, liver)

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins

Chromosome

X (106693794 - 106797016)

Ensembl ID

ENSG00000133135  (ver. 103.38)

Orthologs

Mouse Rnf128: ENSMUSG00000031438

UniProt

Q8TEB7

neXtProt

NX_Q8TEB7

Human splice variants
Mouse splice variants

Protein structure