PRH2

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

Description

Proline rich protein HaeIII subfamily 2

Tissue specificity

Tissue enriched (salivary gland)

Predicted location

Secreted to digestive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

12 (10929236 - 10934845)

Ensembl ID

ENSG00000134551  (ver. 103.38)

Orthologs

-

UniProt

P02810

neXtProt

NX_P02810

Human splice variants

Protein structure