HOOK1

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Description

Hook microtubule tethering protein 1

Tissue specificity

Tissue enhanced (retina)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (59814786 - 59876322)

Ensembl ID

ENSG00000134709  (ver. 103.38)

Orthologs

Mouse Hook1: ENSMUSG00000028572

UniProt

Q9UJC3

neXtProt

NX_Q9UJC3

Human splice variants
Mouse splice variants

Protein structure