Tissue expression
Cell line expression
Protein structure
ERCC5
ERCC excision repair 5, endonucleaseERCM2, XPGC
This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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Proteintech Group | 11331-1-AP | 13 references | Polyclonal |
WB
EL
ICC
IP |
|
Novus Biologicals | NBP2-50366 | Monoclonal |
WB
EL
ICC
IP
IHC
FC |
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Invitrogen Antibodies | PA5-102437 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
antibodies-online | ABIN261688 | 2 references | Polyclonal |
WB
ICC
IP
IHC |
|
NovoPro Bioscience Inc. | 116992 | Polyclonal |
WB
EL
ICC
IP |
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