TES

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Mar 2011]

Description

Testin LIM domain protein

Tissue specificity

Tissue enhanced (seminal vesicle)

Subcell location

Plasma membrane, Cell Junctions, Focal adhesion sites, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (116210506 - 116258783)

Ensembl ID

ENSG00000135269  (ver. 103.38)

Orthologs

-

UniProt

Q9UGI8

neXtProt

NX_Q9UGI8

Human splice variants

Protein structure