KCNH3

The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Description

Potassium voltage-gated channel subfamily H member 3

Tissue specificity

Group enriched (brain, pituitary gland)

Subcell location

Nucleoplasm, Mitochondria

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

12 (49539030 - 49558337)

Ensembl ID

ENSG00000135519  (ver. 103.38)

Orthologs

Mouse Kcnh3: ENSMUSG00000037579

UniProt

Q9ULD8

neXtProt

NX_Q9ULD8

Human splice variants
Mouse splice variants

Protein structure