NMBR

This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Description

Neuromedin B receptor

Tissue specificity

Tissue enhanced (brain, testis)

Subcell location

Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins

Chromosome

6 (142058330 - 142088799)

Ensembl ID

ENSG00000135577  (ver. 103.38)

Orthologs

Mouse Nmbr: ENSMUSG00000019865

UniProt

P28336

neXtProt

NX_P28336

Human splice variants
Mouse splice variants

Protein structure