Tissue expression
Cell line expression
Protein structure
NUDT15
Nudix hydrolase 15FLJ10956, MTH2
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]
Top validated antibodies |
|||||
antibodies-online | ABIN953779 | 2 references | Polyclonal |
WB
IHC
FC
|
|
NSJ Bioreagents | F54345 | Polyclonal |
WB
IHC
FC
|
||
Invitrogen Antibodies | PA5-24507 | Polyclonal |
WB
IHC
FC
|
||
OriGene | AP52959PU-N | Polyclonal |
WB
IHC
FC
|
||
ProSci | 55-574 | Polyclonal |
WB
IHC
FC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider