ST6GALNAC4

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

Tissue specificity

Tissue enhanced (pancreas)

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

9 (127907886 - 127917041)

Ensembl ID

ENSG00000136840  (ver. 103.38)

Orthologs

Mouse St6galnac4: ENSMUSG00000079442

UniProt

Q9H4F1

neXtProt

NX_Q9H4F1

Human splice variants
Mouse splice variants

Protein structure