Tissue expression
Cell line expression
Protein structure
USP20
Ubiquitin specific peptidase 20KIAA1003
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]
Top validated antibodies |
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Proteintech Group | 17491-1-AP | 4 references | Polyclonal |
WB
EL
IP
IHC |
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Invitrogen Antibodies | 17491-1-AP | Polyclonal |
WB
IP
IHC
OA |
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Novus Biologicals | NB100-1260 | 1 references | Polyclonal |
WB
EL
IHC
|
|
antibodies-online | ABIN249927 | 1 references | Polyclonal |
WB
EL
IHC
|
|
NovoPro Bioscience Inc. | 116598 | Polyclonal |
WB
EL
IP
IHC |
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