KIF12

This gene encodes a member of the kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A similar protein in mouse functions in the beta cell antioxidant signaling cascade, acting as a scaffold for the transcription factor specificity protein 1 (Sp1). Mice that lack this gene exhibit beta cell oxidative stress resulting in hypoinsulinemic glucose intolerance. [provided by RefSeq, Jul 2016]

Description

Kinesin family member 12

Tissue specificity

Tissue enhanced (kidney, pancreas)

Subcell location

Golgi apparatus, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

9 (114086126 - 114099291)

Ensembl ID

ENSG00000136883  (ver. 103.38)

Orthologs

Mouse Kif12: ENSMUSG00000028357

UniProt

Q96FN5

neXtProt

NX_Q96FN5

Human splice variants
Mouse splice variants

Protein structure