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TPMT
Thiopurine S-methyltransferaseThis gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Top validated antibodies |
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| Novus Biologicals |  H00007172-M01 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Proteintech Group | 10682-1-AP |
1 references | Polyclonal |
WB
EL
ICC
IHC
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| Abnova Corporation | H00007172-M01 |
2 references | Monoclonal |
WB
ICC
IHC
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| LSBio | LS-B10634 |
Polyclonal |
WB
EL
IP
IHC
|
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| Biorbyt | orb2325153 |
Recombinant |
WB
ICC
IP
IHC
FC
|
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