Tissue expression
Cell line expression
Protein structure
CASP5
Caspase 5ICE(rel)III
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
Top validated antibodies |
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Novus Biologicals | NB120-10454 | 41 references | Monoclonal |
WB
EL
ICC
IP
IHC
|
|
antibodies-online | ABIN265762 | 23 references | Monoclonal |
WB
EL
ICC
IP
IHC
|
|
Boster Biological Technology | A05259-4 | 1 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
|
NSJ Bioreagents | RQ6370 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Biorbyt | orb745901 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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