PLCB2

The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]

Description

Phospholipase C beta 2

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (40278176 - 40307935)

Ensembl ID

ENSG00000137841  (ver. 103.38)

Orthologs

Mouse Plcb2: ENSMUSG00000040061

UniProt

Q00722

neXtProt

NX_Q00722

Human splice variants
Mouse splice variants

Protein structure