MMRN1

Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq, Jul 2008]

Description

Multimerin 1

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (89879532 - 89954629)

Ensembl ID

ENSG00000138722  (ver. 103.38)

Orthologs

Mouse Mmrn1: ENSMUSG00000054641

UniProt

Q13201

neXtProt

NX_Q13201

Human splice variants
Mouse splice variants

Protein structure